Example script to stop following a user.

examples/unfollow_user.py

@@ -0,0 +1,20 @@
+from twython import Twython, TwythonError
+
+# Optionally accept user data from the command line (or elsewhere).
+#
+# Usage: unfollow_user.py Not_So_Cool_Really
+
+import sys
+
+if len(sys.argv) >= 2:
+    target = sys.argv[1]
+else:
+    target = raw_input("User to follow: ")  # For Python 3.x use: target = input("User to follow: ")
+
+# Requires Authentication as of Twitter API v1.1
+twitter = Twython(APP_KEY, APP_SECRET, OAUTH_TOKEN, OAUTH_TOKEN_SECRET)
+
+try:
+    twitter.destroy_friendship(screen_name=target)
+except TwythonError as e:
+    print(e)